A Short History of Cryonics and a long, hard look at the lessons we can learn from it by Charles Platt Vice President, CryoCare Foundation The "Impossible" Dream The dream of escaping mortality has tantalized humanity for thousands of years. It occurs in all primitive cultures and modern world religions. Even Buddhism, which rejects the concept of an afterlife, offers the solace of reincarnation. Clearly, there is a natural human yearning to transcend the limits imposed on us by our physical form. In the twentieth century, for the first time, scientific evidence finally provided rational hope that the dream might become a reality. In 1940, pioneer biologist Basil Luyet published a work titled "Life and Death at Low Temperatures" in which he described his experiments freezing living cells. Luyet observed that many organisms were damaged irrevocably by physical and chemical changes which were triggered by the freezing process, but in some cases he managed to restore normal function when organisms were rewarmed after freezing. Cryobiology Luyet's work led a team of British scientists to establish a whole new area of science which they named _cryobiology._ By soaking cells in a solution of glycerol, they minimized ice damage. Using this _cryoprotectant,_ they were able to freeze red blood cells and bull semen, then restore their functions completely after rewarming, thus proving that life can, in fact, be stopped and restarted under controlled conditions. If such a thing as a "life force" exists, it seems to survive the frozen state. The Promotion of Cryonics In the United States, an American physics professor named Robert Ettinger saw that the discoveries in cryobiology had important implications for human beings. In 1964, his book _The Prospect of Immortality_ promoted the idea that a person frozen after legal death might rationally hope to be resuscitated at some time in the far future when medicine has acquired the ability to cure most diseases, reverse the aging process, and repair any residual damage caused by freezing. The name that was applied to Ettinger's concept was _cryonics._ This distinguishes the freezing of human beings from _cryogenics,_ the general science of low temperatures. Initially, cryobiologists reserved judgment regarding cryonics. But as Ettinger began appearing on talk shows and sensationalistic media coverage began to snowball, many scientists started to distance themselves from the concept, perhaps fearing that they might lose credibility or funding. As a result, there has been very little research into reversible cryopreservation of mammals since the 1960s. Suda's Breakthrough One of the last and most important experiments at a conventionally funded laboratory took place in 1966, when Japanese scientist Isamu Suda froze isolated cat brains after perfusing them with glycerol, then rewarmed them under carefully controlled conditions. Electroencephalograph traces showed that the brains regained some function, even though they had been frozen for a month or more. Suda's paper describing this work was published in _Nature,_ the most prestigious journal of the biological sciences. The Activists Some readers were irrevocably changed by "The Prospect of Immortality," which seemed to offer hope where none had existed before. They wrote to Ettinger asking what was being done to turn cryonics into a reality, and they were dismayed when he told them that no money was being spent on research and no organization was planning to offer cryonics services to the general public. A few activists decided to take matters into their own hands. In 1965, the Cryonics Society of New York (CSNY) was formed, followed in 1966 by the Cryonics Society of Michigan (CSM) and the Cryonics Society of California (CSC). Though they lacked medically qualified personnel and could not afford equipment to perfuse patients properly with cryoprotectant, these groups pronounced themselves ready to freeze people to the best of their limited abilities. They hoped that in the distant future, science would be able to undo the damage caused by their primitive procedures. This was a hit-and-miss approach, but it was better than nothing. Few people signed up with these gifted amateurs, and membership of cryonics societies grew very slowly. The activists remained tireless in their attempts to convince the public that cryonics was the greatest idea of the century, but their technical abilities lagged far behind their enthusiasm, and for a long time, cryonics suffered from lack of money and expertise. The First Cryonaut In 1967, CSC president Robert Nelson led a team that cryopreserved the first man. Nelson was a TV repair man who nevertheless presented himself as a visionary leading a movement which would make its mark on human history. He had a gift for infecting other people with his sense of destiny, but in the long term, he lacked the resources to follow through. CSC was chronically short of money, even while Nelson circulated plans for huge "cryotoriums" which he hoped would house thousands of cryonics patients. The gap between his grand dreams and reality would ultimately prove fatal--to CSC and to its patients. The Chatsworth Scandal CSC froze half-a-dozen people over the next few years. Some were "charity cases" while others were financed by relatives who agreed to pay storage costs on an indefinite basis. Almost unanimously, the relatives defaulted on their commitments, depriving Nelson of necessary cash-flow. Inexcusably (Nelson claims it was an accident), deliveries of liquid nitrogen were allowed to lapse, and the patients thawed in their tanks. It wasn't until 1978 that the scandal became public. An attorney for relatives of one of the patients led journalists to the Oakwood Memorial Park in Chatsworth, California, where they opened an underground vault owned by CSC and saw for themselves that the patients had not been maintained. A law suit followed, and the same relatives who had failed to make maintenance payments accused Robert Nelson of causing them severe mental suffering. Nelson, and the mortician who had assisted him, were assessed substantial damages. The Chatsworth scandal remains unique in cryonics history. Other organizations were also short of cash but were run on highly ethical principles and avoided any breach of their responsibility toward patients and relatives. In New York, under the leadership of Curtis Henderson and Saul Kent, CSNY successfully froze several people, none of whom was neglected because of insufficient funds. (In the end, most of CSNY's patients were reclaimed by relatives who arranged for care elsewhere.) Still, the impact of the Chatsworth scandal was sufficient to tarnish the image of cryonics, and the late 1970s were a moribund period in which little growth occurred. Private Research Meanwhile, a young man in Indianapolis named Michael Federowicz was determined to elevate cryonics to the level of legitimate medical science. Federowicz had been nicknamed "Mike Darwin" at school, because he believed in evolution and rejected creationism. His nickname stuck, and he now uses it as his formal name. Mike established his own cryonics group in Indianapolis and started doing bona-fide animal research, improving the procedures for perfusing and cooling cryonics patients. Meanwhile, another man named Jerry Leaf had also decided to dedicate himself to cryonics research. Leaf was a cardiovascular research scientist at UCLA medical center. In his spare time, he started purchasing his own medical equipment in the hope of pursuing cryonics research on a private basis. Ultimately, Mike Darwin joined Jerry Leaf in the Los Angeles area. With funding from Saul Kent and his business partner William Faloon, they rented a building which they used for research, cooling anesthetized dogs to a couple of degrees above freezing, replacing all their blood with a substitute, and holding the animals with no measurable signs of life for as long as three hours. Most of the dogs were successfully revived and were donated to people as pets. Through their research, Leaf and Darwin proved conclusively that if a "transport team" could be at a patient's beside, ready to administer the necessary drugs and procedures as soon as death was pronounced, the patient could be safely moved to a cryonics facility with minimal injury caused by lack of blood flow. The main beneficiary of these scientific advances was the Alcor Life Extension Foundation, which had been established in 1972 by two former members of CSC who saw the need for a cryonics organization run on a professional, ethical basis. Leaf became the leader of the Alcor cryonic suspension team. Darwin became president of Alcor and subsequently its director of research. Nanotechnology Alcor's technical prowess attracted many new members, and the growth curve became steeper still when a book by Eric Drexler, _The Engines of Creation,_ was published in 1986. Drexler proposed the concept of nanotechnology--machines on the molecular scale, theoretically capable of repairing individual cells. At last, cryonics advocates were able to describe exactly how they hoped future science could undo the freezing damage that still tended to occur even when cryoprotectants were used. Cryonics began to lose its air of wishful thinking, and scientists, physicians, and technically literate professionals in many different fields started to join Alcor in increasing numbers. Modern Cryonics In the late 1980s and early 1990s, The Alcor Foundation experienced phenomenal growth, and the concept of cryonics started receiving unprecedented media exposure--in countless newspaper articles, TV documentaries, and Hollywood movies. Alcor member Charles Platt created the Omni Immortality Contest, which applied conventional promotional techniques to cryonics for the first time. It prompted hundreds of people to write essays explaining why they would like to win the prize of a free cryonic suspension. Four New Organizations By 1993, there were four well-established groups offering cryonics services: Alcor, in Southern California; Robert Ettinger's Cryonics Institute, in Michigan; and The American Cryonics Society and Trans Time Corporation, both located in Northern California. Despite growth in cryonics, none of these organizations could be run on a profitable basis. To some extent, they all required donations in order to cover their operating costs. Under the circumstances, it seemed that cryonics groups should cooperate for mutual strength until a time when cryonics could become more profitable. Unfortunately, there were other factors to consider. In many respects, management skills had lagged behind medical expertise in cryonics. Organizations were still run almost entirely by activists who had little experience in the business world yet were reluctant to seek outside advice. At least one group was so reluctant to change its policies, a large part of its membership felt that it was unresponsive to their views and needs. Consequently, some people broke away to begin an entirely new enterprise which they hoped would be run on a more professional basis. They created not one but four organizations, each specializing in a single aspect of cryonics. The names and functions are as follows: *CryoCare:* Presents cryonics to the general public and signs up customers for cryonic suspension. Receives patients under the Uniform Anatomical Gift Act and takes legal responsibility for their welfare for the indefinite future. *Biopreservation:* Goes to patients and performs medical procedures after legal death is pronounced. Stabilizes patients, perfuses them with cryoprotectant, and takes them down to dry-ice temperature. *CryoSpan:* Cools patients to -196 degrees Celsius, places them in stainless-steel dewars where they are immersed in liquid nitrogen, and care for them until possible restoration. *Independent Patient Care Foundation:* Invests patient funds, yielding income to pay the yearly costs of patient care while keeping the fund principal increasing at least as fast as inflation. Objectives Why so many companies? Because the time has come for cryonics organizations to learn the lessons of history and take steps to insure that past mistakes should never be repeated. By splitting the traditional functions of cryonics into totally separate business entities, various safeguards can be built in, in much the same way that the separation of powers between the legislature, the judiciary, and the presidency helps to maintain stability in our political system. Patient Care Funds are removed from the control of the primary organization, so that they can never be spent on anything other than long-term patient care. After patients have been cryopreserved, they are maintained by a legally separate organization to keep them safe from any legal or financial difficulties that the other businesses may encounter. Maintaining tissues in liquid nitrogen is a well-established medical business that is best kept separate from the more controversial procedures of preparing patients for cryopreservation. Since cryopreservation and storage are offered as services by independent providers, these businesses are motivated not only by their own dedication, but by competition in the free market. CryoCare is also free to find other service providers, giving members a choice that most other organizations do not provide. In 1995, for instance, CryoCare began offering the option of long-term maintenance at the Cryonics Institute as an alternative to CryoSpan. Let's now examine these advantages in more detail. 1. Patient safety. Cryonics is still regarded with deep skepticism by many people--especially government regulators. As a result, cryonics organizations have been faced with more than their share of legal challenges. The Alcor Foundation experienced a crisis in 1988 when it moved one of its patients into its facility prior to cryopreservation, which attracted the attention of the local coroner, whose subsequent investigation placed every Alcor patient in jeopardy. Only a last-minute court order protected the patients from the coroner. We believe that cryopreserved patients can be better protected against government intervention and hostile relatives if they are kept and cared for by a company that is entirely separate from the organization that performs the initial procedures of cryopreservation. 2. Financial security. Cryonics organizations have always tended to be undercapitalized. As a result, sometimesthey have been tempted to use patient-care funds to pay everyday expenses. CryoCare, the company that assumes legal responsibility for the patients, is compelled by its by-laws and contracts to place all patient-care assets with the Independent Patient Care Foundation, an entirely separate organization which reserves the income from a patient's funds strictly for expenses that directly benefit that patient. Moreover, the Independent Patient Care Foundation will be run by successful financial professionals who may not be officers or directors of any other cryonics-related organization. 3. Better service through competition. In the plan above, BioPreservation performs suspensions on a contractual basis. But if other, similar companies enter the field and offer a comparable service, CryoCare members will have the option to choose among them. Conversely, any service provider that fails to offer satisfactory service can be removed from CryoCare's list. This degree of choice, and this performance incentive, have never existed before in cryonics. 4. Better performance through specialization. Of the four main tasks in cryonics--signing up new customers, performing cryopreservation procedures, storing patients, and investing patient funds--each requires a very different mix of skills and experience. Traditionally, in an all-purpose cryonics organization, a few people would attempt to do all the various tasks, from sending out press releases to administering emergency protocol. Our new model recognizes that cryonics is too big and important to be run by generalists with a finger in every pie. Each company can and should have directors and employees with appropriate skills and experience. We also recognize that cryonics activists tend to be independent people who are happier and more productive as entrepreneurs than as a large cooperative group. 5. Realistic assessment of goals. The history of cryonics shows a repeated tendency to be dazzled by our ultimate goal of biological immortality while becoming inattentive to everyday financial details. For example, there has been a recurring obsession with impressive, large-scale building projects without adequate concern for their cost. In the CryoCare model each company has narrower, specific goals, and cash-hungry PR initiatives are isolated from the routine but critical operation of maintaining patients in long-term care. 6. Flexible response to the needs of members and patients. Other cryonics organizations take complete control of the frozen patients. The CryoCare system is more flexible, allowing amembers to nominate one or more Patient Advocates to represent their interests after legal death has been pronounced. While some cryonics organizations are structured to be highly resistant to change, CryoCare's system of Patient Advocates enables properly qualified members to exert some influence over the way that the organization is run. The Future If cryonics is to work, safe and reliable care may have to be provided for a century or more. Setting up a business on this basis, with limited funds and personnel, is a great challenge. CryoCare, and the other new companies whose services it employs, may not be the ultimate answer. It may never be able to eliminate all risk from cryonics. But the multi- organization scenario is the most serious attempt that has ever been made to learn the lessons of history and profit from them. The dream of escaping mortality is powerfully seductive. It is a worthy dream, but it will only come true if it is pursued on a cautious, skeptical, rational basis. Attention to detail, high ethical standards, state-of-the-art medical techniques, continuing research, and impeccable financial management are indispensable if cryonics is to fulfill the promise which first excited public imagination more than twenty-five years ago. These are the principles on which the CryoCare system is founded. How to Contact Cryocare Call toll-free for information: 1-800-TOP-CARE (1-800-867-2273) For inquiries via U.S. Mail: CryoCare Foundation 1013 Centre Road Suite 301 Wilmington, DE 19805-1297 Email address: Web site: http://www.cryocare.org/cryocare/ (c) Copyright 1994 by Charles Platt